Splenectomy for massive splenomegaly.

Partial splenectomy for massive splenomegaly secondary to Gaucher's disease.

A 16 year old girl with Type 1 Gaucher's disease presented with massive splenomegaly, hypersplenism and abdominal discomfort. Traditionally hypersplenism has been treated with splenectomy, but this results in a high incidence of overwhelming sepsis and accelerated sphingolipid deposition in both liver and bone. A 90% partial splenectomy was therefore performed leaving a fully vascularized infer...

Splenectomy for Tropical Splenomegaly

Splenectomy for Splenomegaly

Physician to the Bristol Royal Infirmary.

Massive Splenomegaly in Children: Laparoscopic Versus Open Splenectomy

BACKGROUND AND OBJECTIVES Laparoscopic splenectomy for massive splenomegaly is still a controversial procedure as compared with open splenectomy. We aimed to compare the feasibility of laparoscopic splenectomy versus open splenectomy for massive splenomegaly from different surgical aspects in children. METHODS The data of children aged <12 years with massive splenomegaly who underwent splenec...

Splenectomy in tropical splenomegaly.

"Big Spleen Disease"-Hamilton et al. MEBRITCLSH 825 44%. His only treatment has been a 15-day course of primaquine followed by 100 mg. of proguanil daily. This is further evidence for a malarial cause of this syndrome and also for implicating the spleen in the plasma volume changes. The role of the spleen is also shown by a case of Felty's syndrome (Pengelly, 1966), in which a marked reduction ...